Nichols is a town in Marion County, South Carolina, United States. The population was 408 at the 2000 census.Nichols is located at 34°13′58″N 79°8′55″W / 34.23278°N 79.14861°W / 34.23278; -79.14861.According to the United States Census Bureau, the town has a total area of 1.4 square miles, all land.As of the census of 2000, there were 408 people, 176 households, and 120 families residing in the town. The population density was 293.8 people per square mile. There were 199 housing units at an average density of 143.3 per square mile. The racial makeup of the town was 51.96% White, 47.06% African American, 0.25% Native American, and 0.74% from two or more races.There were 176 households out of which 17.6% had children under the age of 18 living with them, 44.3% were married couples living together, 19.3% had a female householder with no husband present, and 31.8% were non-families. 29.5% of all households were made up of individuals and 13.